Biphasic Mesothelioma is a rare and aggressive histological subtype of malignant mesothelioma, a cancer primarily caused by prolonged exposure to asbestos fibers. It is characterized by the simultaneous presence of two distinct cellular patterns: epithelioid cells, which are relatively structured and more responsive to treatment, and sarcomatoid cells, which are spindle-shaped and highly invasive. The coexistence of both components, each comprising at least 10% of the tumor mass, defines this subtype and significantly influences its prognosis and therapeutic strategy.
Biphasic Mesothelioma
A vivid green-stained cross-section of biphasic mesothelioma tissue, illustrating the dual cellular morphology of this rare mesothelioma subtype under high magnification.