Sarcomatoid Mesothelioma is the most aggressive and least common histological subtype of malignant mesothelioma—a rare, fatal cancer caused by prolonged asbestos exposure. Accounting for approximately 10–20% of all mesothelioma cases, this subtype arises from mesenchymal-like spindle cells and most frequently affects the pleura (lining of the lungs).
Unlike epithelioid mesothelioma, sarcomatoid cells lack cohesion, appearing elongated and irregular under a microscope. This results in rapid local invasion, resistance to chemotherapy, and poor prognosis, with median survival typically under 6–12 months post-diagnosis.