Researchers indicate that pleural mesothelioma may possibly act differently due to a person’s gender, because of different molecular levels. By determining the differing traits based on gender, experts are hoping that treatment options can be customized to help each person in the best way for their own individual needs. The new study helps further the explanation of why women with mesothelioma generally survive longer than men with mesothelioma.
Molecular Differences Study
According to a study carried out by Dr. Assunta De Rienzo of Boston’s Brigham and Women’s Hospital, understanding why it’s been shown that females typically survive longer than males with mesothelioma may come down to the different molecular levels that each gender has, specifically for malignant pleural mesothelioma.
“Insight into the survival advantage of female patients may advance the molecular understanding of malignant pleural mesothelioma (MPM) and identify therapeutic interventions that will improve the prognosis for all MPM patients.”
During the study, 10 patients with malignant mesothelioma were studied, as well as 10 healthy people without the disease. The genomes of male and female mesothelioma patients and the genomes of patients with other forms of mesothelioma were studied. Among the female pleural mesothelioma patients, the TP53 gene was found more frequently, while those with epithelioid mesothelioma were found to have more chromosome 22q loss.
“Collectively, our findings indicate that diverse mechanisms highly related to gender and histology appear to drive malignant pleural mesothelioma,” Dr. De Rienzo said.
Estrogen and Progesterone Study
According to the Annals of Thoracic Surgery, women with mesothelioma typically live longer than men with mesothelioma, even when ages, disease level, and overall health are similar. In one particular study on women and estrogen therapy, published by the International Association for the Study of Lung Cancer, results indicated that women who took estrogen lived over four years longer than those who didn’t. Additionally, if women took both progesterone and estrogen, they survived an additional year.
According to the lead author of the study, Ann G. Schwartz, PhD, MPH
What has emerged from this study and other published findings is a complex relationship between hormone use and lung cancer outcomes, with variation based on years of use.”
Another study showed that women with epithelial tumors have a much longer survival rate when compared to men with similar types of tumors. Yet, both genders with nonepithelial tumors had the same survival rate.
Women and Surgery
Another study carried out by researchers at Brigham and Women’s Hospital showed that women who undergo surgery tend to survive longer than men with mesothelioma who undergo the same type of surgery. In fact, the study showed that extrapleural pneumonectomy (EEP) tends to be much more beneficial to women. In addition, women tend to be diagnosed earlier and generally start treatment options when they are younger and healthier.
Additional Help and Resources for Mesothelioma Patients
If you or a loved one have been diagnosed with mesothelioma or any other illness related to asbestos, you may be eligible for substantial compensation. There is currently over $30 billion in asbestos trust funds, set up for those who are victims to asbestos-related diseases. Use our free Asbestos Attorney Locator Tool today to find a leading mesothelioma attorney in your area. If you need assistance or have any questions, contact us toll-free at 800-694-4856.